Fasl^tm2.1Bksa
Targeted Allele Detail

Summary

• Symbol: Fasl^tm2.1Bksa
• Name: Fas ligand; targeted mutation 2.1, Bruce R Ksander
• MGI ID: MGI:5006688
• Synonyms: FasL^deltaCS
• Gene: Fasl Location: Chr1:161608260-161616064 bp, - strand Genetic Position: Chr1, 69.95 cM
• Alliance: Fasl^tm2.1Bksa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171440
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution within exon 2 resulted in the amino acid substitution of threonine for serine at position 124 (S124T), phenylalanine for leucine at position 125 (L125F), arginine for lysine at position 127 (L127R), and glutamine for asparagine at position 128 (N128Q). These mutations prevent cleavage of the protein to produce the soluble form. The floxed neo cassette used for selection was removed by cre-mediated recombination. (J:171440)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fasl Mutation: 37 strains or lines available

References

• Original: J:171440 Gregory MS, et al., Opposing roles for membrane bound and soluble fas ligand in glaucoma-associated retinal ganglion cell death. PLoS One. 2011;6(3):e17659
• All: 2 reference(s)