Fasl^tm1.1Bksa
Targeted Allele Detail

Summary

• Symbol: Fasl^tm1.1Bksa
• Name: Fas ligand; targeted mutation 1.1, Bruce R Ksander
• MGI ID: MGI:5006689
• Gene: Fasl Location: Chr1:161608260-161616064 bp, - strand Genetic Position: Chr1, 69.95 cM
• Alliance: Fasl^tm1.1Bksa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171440
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Eight residues within exon 2 were deleted resulting in a splicing error and frameshift mutation. Cre-mediated recombination used the floxed neo cassette used for selection. FACS analysis confirmed the absence of Fasl-expressing activated T cells. (J:171440)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fasl Mutation: 37 strains or lines available

References

• Original: J:171440 Gregory MS, et al., Opposing roles for membrane bound and soluble fas ligand in glaucoma-associated retinal ganglion cell death. PLoS One. 2011;6(3):e17659
• All: 1 reference(s)