Myc^tm1.1Cksn
Targeted Allele Detail

Summary

• Symbol: Myc^tm1.1Cksn
• Name: myelocytomatosis oncogene; targeted mutation 1.1, Christian Kosan
• MGI ID: MGI:5006706
• Synonyms: c-Myc V394D KI
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm1.1Cksn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170508
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution results in the amino acid substitution of aspartic acid for valine at position 394 (V394D). The floxed neo cassette inserted into exon 3 was removed by cre-mediated recombination. (J:170508)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 43 strains or lines available

References

• Original: J:170508 Saba I, et al., IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. Blood. 2011 Mar 24;117(12):3370-81
• All: 2 reference(s)