Ikbke^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Ikbke^tm1Dgen
• Name: inhibitor of kappaB kinase epsilon; targeted mutation 1, Deltagen
• MGI ID: MGI:5006718
• Gene: Ikbke Location: Chr1:131182337-131207339 bp, - strand Genetic Position: Chr1, 56.93 cM
• Alliance: Ikbke^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171942
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 904 bp of the coding region was replaced with an IRES-lacZ reporter and neo cassette. The absence of protein expression was confirmed by western blot analysis on liver and white adipose tissue extracts. (J:171942)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikbke Mutation: 55 strains or lines available

References

• Original: J:171942 Scheja L, et al., Beneficial effects of IKKepsilon-deficiency on body weight and insulin sensitivity are lost in high fat diet-induced obesity in mice. Biochem Biophys Res Commun. 2011 Apr 8;407(2):288-94
• All: 1 reference(s)