Snap23^tm1.2Paro
Targeted Allele Detail

Summary

• Symbol: Snap23^tm1.2Paro
• Name: synaptosomal-associated protein 23; targeted mutation 1.2, Paul A Roche
• MGI ID: MGI:5006857
• Synonyms: Snap23^fl
• Gene: Snap23 Location: Chr2:120398152-120431736 bp, + strand Genetic Position: Chr2, 60.37 cM, cytoband E5
• Alliance: Snap23^tm1.2Paro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171444
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A floxed neo cassette was inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. Protein expression is reduced in brains from heterozygous mice. (J:158506, J:171444)

Generation of the Snap23^tm1Paro, Snap23^tm1.1Paro, and Snap23^tm1.2Paro alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snap23 Mutation: 31 strains or lines available

References

• Original: J:171444 Suh YH, et al., Deletion of SNAP-23 Results in Pre-Implantation Embryonic Lethality in Mice. PLoS One. 2011;6(3):e18444
• All: 3 reference(s)