Tg(Mov1/Tyr)OVE876BPay
Transgene Detail

Summary

• Symbol: Tg(Mov1/Tyr)OVE876BPay
• Name: transgene insertion OVE876B, Richard Paylor
• MGI ID: MGI:5006860
• Synonyms: MALTT, multiple autistic-like trait transgenic
• Transgene: Tg(Mov1/Tyr)OVE876BPay Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(Mov1/Tyr)OVE876BPay page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: Sequences from the 5' end of the Moloney murine leukemia virus were linked to a tyrosinase minigene consisting of a 2.1-kb promoter linked to a 1.9-kb tyrosinase cDNA. Expression of the tyrosinase minigene leads to melanin synthesis in the skin and fur. The transgene inserted in the non-coding region between Gm732 and Brwd3 on chromosome X. PCR amplification with minigene-only primer sets suggests that at minimum 2 copies inserted in tandem, while Southern blot hybridization indicates a maximum of 4 copies inserted together. Expression of Fam46d, located near the site of transgenic intergration, is upregulated. (J:167614)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:167614 Hamilton SM, et al., Multiple autism-like behaviors in a novel transgenic mouse model. Behav Brain Res. 2011 Mar 17;218(1):29-41
• All: 1 reference(s)