Pak2tm1.1Rjak
Targeted Allele Detail
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Symbol: |
Pak2tm1.1Rjak |
Name: |
p21 (RAC1) activated kinase 2; targeted mutation 1.1, Rolf Jakobi |
MGI ID: |
MGI:5006978 |
Synonyms: |
PAK-2D212N-Neo- |
Gene: |
Pak2 Location: Chr16:31835108-31898160 bp, - strand Genetic Position: Chr16, 22.4 cM
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Alliance: |
Pak2tm1.1Rjak page
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Allele Type: |
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Targeted (Not Specified) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Nucleotide substitutions in exon 7 result in the amino acid substitution of asparagine for aspartic acid at position 212 (D212N). A floxed neo cassette was inserted downstream of the modified exon 7. Cre-mediated recombination removed the neo cassette and allowed for expression of the knock-in transcript. The knock-in product is caspase-cleavage deficient.
(J:171914)
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Generation of the Pak2tm1.1Rjak allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pak2 Mutation: |
66 strains or lines available
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Original: |
J:171914 Marlin JW, et al., Functional PAK-2 knockout and replacement with a caspase cleavage-deficient mutant in mice reveals differential requirements of full-length PAK-2 and caspase-activated PAK-2p34. Mamm Genome. 2011 Jun;22(5-6):306-17 |
All: |
1 reference(s) |
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