Axin2^canp
Chemically induced Allele Detail

Summary

• Symbol: Axin2^canp
• Name: axin 2; canopus
• MGI ID: MGI:5006982
• Synonyms: canp
• Gene: Axin2 Location: Chr11:108811175-108841609 bp, + strand Genetic Position: Chr11, 71.83 cM
• Alliance: Axin2^canp page

Embryonic morphogenesis is disrupted in Axin2^canp/Axin2^canp embryos

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU treatment induced a T-to-A mutation, resulting in a valine to aspartic acid substitution at amino acid 26 (p.V26D) in an invariant N-terminal sequence motif. Western blot analysis indicated protein expression was increased 1.6 and 2.2 fold in heterozygous and homozygous embryos, respectively, relative to wild-type mice. Protein half-life is increased in homozygous MEFs relative to wild-type MEFs. (J:98216, J:171894)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Axin2 Mutation: 44 strains or lines available

References

• Original: J:171894 Qian L, et al., Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8692-7
• All: 2 reference(s)