Adam18^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Adam18^tm1Lex
• Name: a disintegrin and metallopeptidase domain 18; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:5007009
• Gene: Adam18 Location: Chr8:25092262-25164771 bp, - strand Genetic Position: Chr8, 12.82 cM, cytoband A3
• Alliance: Adam18^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The Adam18 gene consists of 20 exons, with the start codon located in exon 1 (NCBI accession NM_010084.1). Exons 1 and 2 were targeted by homologous recombination. Disruption of the target gene was confirmed by Southern hybridization analysis. (J:171883)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adam18 Mutation: 75 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
• All: 2 reference(s)