Jam3^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Jam3^tm1Lex
• Name: junction adhesion molecule 3; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:5007203
• Gene: Jam3 Location: Chr9:27008680-27066717 bp, - strand Genetic Position: Chr9, 12.27 cM
• Alliance: Jam3^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was replaced with a LacZ/Neo cassette via homologous recombination. Western blot analysis confirmed loss of protein expression. (J:145994, J:171883)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Jam3 Mutation: 24 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
• All: 6 reference(s)