Nrros^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Nrros^tm1Lex
• Name: negative regulator of reactive oxygen species; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:5007223
• Synonyms: Lrrc33^tm1Lex
• Gene: Nrros Location: Chr16:31961603-31984412 bp, - strand Genetic Position: Chr16, 22.4 cM
• Alliance: Nrros^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 4, wich codes for the bulk of the protein, was replaced with a beta-galactosidase reporter and neomycin/puromycin resistance gene cassette. (J:171883, J:209569)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nrros Mutation: 37 strains or lines available

References

• Original: J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
• All: 4 reference(s)