Tmem107^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Tmem107^tm1Lex
• Name: transmembrane protein 107; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:5007367
• Synonyms: Tmem107^-
• Gene: Tmem107 Location: Chr11:68961635-68964119 bp, + strand Genetic Position: Chr11, 42.35 cM, cytoband B3
• Alliance: Tmem107^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 1 through 5 were replaced with the targeting vector. (J:171883)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tmem107^tm1Lex/Tmem107^tm1Lex	B6N.129S5(Cg)-Tmem107^tm1Lex/Mmucd
ht2	Tmem107^schlei/Tmem107^tm1Lex	involves: 129S5/SvEvBrd * C3HeB/FeJ * C57BL/6J * C57BL/6N

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms
cellular	√
abnormal primary cilium morphology	√
craniofacial	√
abnormal craniofacial morphology	√
abnormal cranium morphology	√
abnormal basisphenoid bone morphology	√
impaired ossification of basisphenoid bone	√
short Meckel's cartilage	√
abnormal cranial cartilage development	√
small frontal bone	√
small parietal bone	√
abnormal mandible morphology	√
short mandible	√
abnormal maxilla morphology	√
decreased maxillary shelf size	√
abnormal premaxilla morphology	√
small maxilla	√
abnormal palatine bone morphology	√
small zygomatic bone	√
abnormal facial morphology	√
absent nasal bone	√
small nasal bone	√
abnormal palatal mesenchymal cell proliferation	√
abnormal palatal shelf morphology	√
abnormal palatal shelf bone ossification	√
palatal shelves fail to meet at midline	√
cleft upper lip	√
unilateral cleft upper lip	√
abnormal palatal rugae morphology	√
cleft palate	√
cleft secondary palate	√
abnormal palatal shelf elevation	√
abnormal tongue morphology	√
abnormal tongue position	√
decreased tongue size	√
abnormal nasal septum cartilage morphology	√
abnormal vomeronasal cartilage morphology	√
abnormal vomeronasal organ morphology	√
large nasal septum	√
thick nasal septum	√
abnormal snout morphology	√
broad snout	√
short snout	√
abnormal head shape	√
digestive/alimentary system	√
decreased maxillary shelf size	√
abnormal palatal mesenchymal cell proliferation	√
abnormal palatal shelf morphology	√
abnormal palatal shelf bone ossification	√
palatal shelves fail to meet at midline	√
abnormal palatal rugae morphology	√
cleft palate	√
cleft secondary palate	√
abnormal palatal shelf elevation	√
abnormal tongue morphology	√
abnormal tongue position	√
decreased tongue size	√
embryo	√	√
abnormal neural tube morphology	√
absent floor plate	√	√
growth/size/body	√
abnormal facial morphology	√
decreased maxillary shelf size	√
absent nasal bone	√
small nasal bone	√
abnormal palatal mesenchymal cell proliferation	√
abnormal palatal shelf morphology	√
abnormal palatal shelf bone ossification	√
palatal shelves fail to meet at midline	√
cleft upper lip	√
unilateral cleft upper lip	√
abnormal palatal rugae morphology	√
cleft palate	√
cleft secondary palate	√
abnormal palatal shelf elevation	√
abnormal tongue morphology	√
abnormal tongue position	√
decreased tongue size	√
abnormal nasal septum cartilage morphology	√
abnormal vomeronasal cartilage morphology	√
abnormal vomeronasal organ morphology	√
large nasal septum	√
thick nasal septum	√
abnormal snout morphology	√
broad snout	√
short snout	√
abnormal head shape	√
limbs/digits/tail	√	√
preaxial polydactyly	√	√
mortality/aging	√
prenatal lethality, complete penetrance	√
nervous system	√	√
abnormal vomeronasal organ morphology	√
abnormal neural tube morphology	√
absent floor plate	√	√
exencephaly	√
optic nerve hypoplasia	√
respiratory system	√
absent nasal bone	√
small nasal bone	√
abnormal nasal septum cartilage morphology	√
abnormal vomeronasal cartilage morphology	√
abnormal vomeronasal organ morphology	√
large nasal septum	√
thick nasal septum	√
skeleton	√
abnormal cranium morphology	√
abnormal basisphenoid bone morphology	√
impaired ossification of basisphenoid bone	√
short Meckel's cartilage	√
abnormal cranial cartilage development	√
small frontal bone	√
small parietal bone	√
abnormal mandible morphology	√
short mandible	√
abnormal maxilla morphology	√
decreased maxillary shelf size	√
abnormal premaxilla morphology	√
small maxilla	√
absent nasal bone	√
small nasal bone	√
abnormal palatine bone morphology	√
small zygomatic bone	√
abnormal nasal septum cartilage morphology	√
abnormal vomeronasal cartilage morphology	√
abnormal intramembranous bone ossification	√
abnormal palatal shelf bone ossification	√
delayed intramembranous bone ossification	√
vision/eye	√
optic nerve hypoplasia	√
abnormal eye development	√
microphthalmia	√
anophthalmia	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	29 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tmem107 Mutation: 21 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
• All: 7 reference(s)