Tmem108^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Tmem108^tm1Lex
• Name: transmembrane protein 108; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:5007368
• Gene: Tmem108 Location: Chr9:103360146-103639036 bp, - strand Genetic Position: Chr9, 55.47 cM
• Alliance: Tmem108^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Hypomorph, Reporter)
• Mutation: Intragenic deletion
• Mutation details: A lacZ/neomycin cassette was targeted at exon 3 (the first coding exon) by homologous recombination. Exon 3 is partially deleted which generates a premature stop codon. qRT-PCR and Western blot analysis showed that RNA and protein levels were drastically reduced in the hippocampus. (J:171883, J:239156)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tmem108 Mutation: 29 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
• All: 5 reference(s)