Tmem178^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Tmem178^tm1Lex
• Name: transmembrane protein 178; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:5007374
• Synonyms: Tmem178^-
• Gene: Tmem178 Location: Chr17:81252061-81309245 bp, + strand Genetic Position: Chr17, 50.97 cM, cytoband E3
• Alliance: Tmem178^tm1Lex page

Trabecular thinning and increase in osteoclast surface normalized to bone surface in Tmem178^tm1Lex/Tmem178^tm1Lex mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• A portion of the coding region was targeted by homologous recombination. (J:171883)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tmem178 Mutation: 13 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
• All: 4 reference(s)