Tmub1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Tmub1^tm1Lex
• Name: transmembrane and ubiquitin-like domain containing 1; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:5007386
• Gene: Tmub1 Location: Chr5:24650456-24652852 bp, - strand Genetic Position: Chr5, 11.79 cM, cytoband A3
• Alliance: Tmub1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The Tmub1 gene consists of 3 exons. Coding exons 1 and 2 were targeted (NCBI accession NM_022418.1) by homologous recombination and replaced with a LacZ/neomycin selection cassette. Disruption of the target gene was confirmed by Southern hybridization analysis and multiplex PCR. (J:161786, J:171883)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tmub1 Mutation: 23 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
• All: 3 reference(s)