Zdhhc9^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Zdhhc9^tm1Lex
• Name: zinc finger, DHHC domain containing 9; targeted mutation 1, Lexicon Pharmaceuticals
• MGI ID: MGI:5007410
• Gene: Zdhhc9 Location: ChrX:47260846-47297755 bp, - strand Genetic Position: ChrX, 25.55 cM
• Alliance: Zdhhc9^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The Zdhhc9 gene consists of 10 exons. Coding exon 1 was targeted (NCBI accession NM_172465.1) by homologous recombination, whereby a genomic region of 207 bp including most of the first coding exon (exon2) was deleted. A selection cassette containing both neomycin and lacZ was also inserted. Western blot analysis of whole brain lysates confirmed the absence of full-length and any truncated protein fragment. (J:171883, J:268248)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Zdhhc9 Mutation: 6 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
• All: 6 reference(s)