Fbxw7^tm1Itom
Targeted Allele Detail

Summary

• Symbol: Fbxw7^tm1Itom
• Name: F-box and WD-40 domain protein 7; targeted mutation 1, Ian Tomlinson
• MGI ID: MGI:5007620
• Synonyms: Fbxw7^flox, Fbxw7^fl(R482Q)
• Gene: Fbxw7 Location: Chr3:84722575-84886505 bp, + strand Genetic Position: Chr3, 37.7 cM, cytoband E3.3
• Alliance: Fbxw7^tm1Itom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172214
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Single point mutation
• Mutation details: A loxP site was inserted upstream of exon 9 and a floxed neo cassette and a 3.6 kb genomic fragment of Fbxw7 including a G to A mutation resulting in an arginine to glutamine substitution at position 482 was inserted after the polyA sequence. (J:172214)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fbxw7^tm1Itom

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxw7 Mutation: 84 strains or lines available

References

• Original: J:172214 Davis H, et al., FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J Pathol. 2011 Jun;224(2):180-9
• All: 3 reference(s)