Tg(Myh6-Tpm1*E180G)57Dfw
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tpm1*E180G)57Dfw
• Name: transgene insertion 57, David F Wieczorek
• MGI ID: MGI:5007645
• Synonyms: FHC alpha-TM 180, TM180, Tm-E180G
• Transgene: Tg(Myh6-Tpm1*E180G)57Dfw Location: unknown
• Alliance: Tg(Myh6-Tpm1*E180G)57Dfw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tpm1*E180G)57Dfw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tpm1 (MGI:98809)	Transgene codes for a protein with a glutamic acid to glycine mutation.

• Mutation details: This transgene consists of the murine alpha-myosin heavy chain cardiac-specific promoter ligated to the 5' end of the mouse alpha-tropomyosin with a single point mutation (GAG to GGG) corresponding to a glycine substitution for a glutamic acid at codon 180. This region interacts with troponin T. Quantification of the transgene demonstrates that copy number in line 57 is 22 copies. (J:127507, J:172340)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Four lines, 33, 52, 57, and 58 were made (J:172340).

References

• Original: J:127507 Prabhakar R, et al., A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice. J Mol Cell Cardiol. 2001 Oct;33(10):1815-28
• All: 17 reference(s)