Apoe^tm4Mae
Targeted Allele Detail

Summary

• Symbol: Apoe^tm4Mae
• Name: apolipoprotein E; targeted mutation 4, Nobuyo Maeda
• MGI ID: MGI:5007656
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^tm4Mae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172417
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Part of exon 3 and intron 3 were replaced with a neomycin resistance cassette. (J:172417)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 156 strains or lines available

References

• Original: J:172417 Maeda N, et al., Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgrounds. Atherosclerosis. 2007 Nov;195(1):75-82
• All: 7 reference(s)