Tph2^tm1.1Zfc
Targeted Allele Detail

Summary

• Symbol: Tph2^tm1.1Zfc
• Name: tryptophan hydroxylase 2; targeted mutation 1.1, Zhou-Feng Chen
• MGI ID: MGI:5007662
• Gene: Tph2 Location: Chr10:114914546-115020927 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Tph2^tm1.1Zfc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170988
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5 and the selection cassette. (J:170988)

Expression

In Mice Carrying this Mutation:

73 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph2 Mutation: 43 strains or lines available

References

• Original: J:170988 Liu Y, et al., Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature. 2011 Apr 7;472(7341):95-9
• All: 10 reference(s)