Agtr1a^tm1.1Cof
Targeted Allele Detail

Summary

• Symbol: Agtr1a^tm1.1Cof
• Name: angiotensin II receptor, type 1a; targeted mutation 1.1, Thomas M Coffman
• MGI ID: MGI:5007680
• Synonyms: Agtr1a^flox
• Gene: Agtr1a Location: Chr13:30520424-30566850 bp, + strand Genetic Position: Chr13, 13.19 cM
• Alliance: Agtr1a^tm1.1Cof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172240
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 3 floxed. (J:172240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agtr1a Mutation: 40 strains or lines available

References

• Original: J:172240 Gurley SB, et al., AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011 Apr 6;13(4):469-75
• All: 16 reference(s)