Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Merck Research Laboratory |
MGI ID: |
MGI:5007772 |
Synonyms: |
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1,CAG-tetR)Mrl, Rosa26PDK1-RNAi |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:170965
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inducible, Knockdown) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl involves 1 genes/genome features (Pdpk1)
View all
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Mutation details: A construct containing a short hairpin RNA targeting Pdpk1 driven by the H1/tetO operator fusion promoter and a floxed CAG promoter driving expression of the tetR regulatory cassette was inserted into the locus.
(J:170965)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
986 strains or lines available
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Original: |
J:170965 Ellwood-Yen K, et al., PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models. Cancer Res. 2011 Apr 15;71(8):3052-65 |
All: |
1 reference(s) |
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