Gt(ROSA)26Sor^{tm2(H1/tetO-RNAi:Pdpk1)Mrl}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(H1/tetO-RNAi:Pdpk1)Mrl}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Merck Research Laboratory
• MGI ID: MGI:5007773
• Synonyms: Gt(ROSA)26Sor^{tm2(H1/tetO-RNAi:Pdpk1,CAG-tetR)Mrl}, Rosa26^PDK-RNAi(2)
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(H1/tetO-RNAi:Pdpk1)Mrl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170965
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Knockdown)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(H1/tetO-RNAi:Pdpk1)Mrl} involves 1 genes/genome features (Pdpk1) View all
• Mutation details: A construct containing a short hairpin RNA targeting Pdpk1 driven by the H1/tetO operator fusion promoter and a floxed CAG promoter driving expression of the tetR regulatory cassette was inserted into the locus. (J:170965)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:170965 Ellwood-Yen K, et al., PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models. Cancer Res. 2011 Apr 15;71(8):3052-65
• All: 1 reference(s)