Masp2^tm1Wjsc
Targeted Allele Detail

Summary

• Symbol: Masp2^tm1Wjsc
• Name: MBL associated serine protease 2; targeted mutation 1, Wilhelm J Schwaeble
• MGI ID: MGI:5007776
• Gene: Masp2 Location: Chr4:148687011-148699956 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Masp2^tm1Wjsc page

Masp2^tm1Wjsc/Masp2^tm1Wjsc mice exhibit reduced myocardial ischemia/reperfusion injury-induced myocardial damage

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172218
• Parent Cell Line: E14.1a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 11 and 12 were replaced with a neo cassette via homologous recombination. Absence of mRNA and protein expression were confirmed by northern blotting, qRT-PCR, ELISA, and western blotting. (J:172218)

Generation of the Masp2^tm1Wjsc allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Masp2 Mutation: 35 strains or lines available

References

• Original: J:172218 Schwaeble WJ, et al., Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7523-8
• All: 7 reference(s)