Mefv^tm6Chae
Targeted Allele Detail

Summary

• Symbol: Mefv^tm6Chae
• Name: Mediterranean fever; targeted mutation 6, Jae Jin Chae
• MGI ID: MGI:5007915
• Gene: Mefv Location: Chr16:3525082-3535961 bp, - strand Genetic Position: Chr16, 2.18 cM
• Alliance: Mefv^tm6Chae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172117
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1 and 2 were replaced with a neo cassette. (J:172117)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mefv Mutation: 46 strains or lines available

References

• Original: J:172117 Chae JJ, et al., Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1beta Activation and Severe Autoinflammation in Mice. Immunity. 2011 May 27;34(5):755-68
• All: 5 reference(s)