Lrrk2^tm1Mjfa
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm1Mjfa
• Name: leucine-rich repeat kinase 2; targeted mutation 1, Matthew Farrer
• MGI ID: MGI:5008465
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm1Mjfa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172418
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector containing a PGK-neo cassette was used to insert loxP sites flanking exon 41 and the selection cassette. Cre-mediated recombination removed exon 41 and the FRT-flanked neo cassette. (J:172418, J:188435)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 159 strains or lines available

References

• Original: J:172418 Dachsel JC, et al., A comparative study of Lrrk2 function in primary neuronal cultures. Parkinsonism Relat Disord. 2010 Dec;16(10):650-5
• All: 18 reference(s)