Lrrk2^tm2Mjfa
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm2Mjfa
• Name: leucine-rich repeat kinase 2; targeted mutation 2, Matthew Farrer
• MGI ID: MGI:5008466
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm2Mjfa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172418
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions (GGG to AGC) in exon 41 results in the amino acid substitution of serine for glycine at position 2019 (G2019S). Cre-mediated recombination removed the selection cassette. (J:172418, J:242269)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 159 strains or lines available

References

• Original: J:172418 Dachsel JC, et al., A comparative study of Lrrk2 function in primary neuronal cultures. Parkinsonism Relat Disord. 2010 Dec;16(10):650-5
• All: 3 reference(s)