Aspa^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Aspa^{tm1c(EUCOMM)Wtsi}
• Name: aspartoacylase; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5008602
• Synonyms: aspa^f
• Gene: Aspa Location: Chr11:73195813-73217677 bp, - strand Genetic Position: Chr11, 45.28 cM, cytoband B4
• Alliance: Aspa^{tm1c(EUCOMM)Wtsi} page
• IMPC: Aspa gene page

Mutation origin

• Mutant Cell Line: EPD0038_4_C09
• Germline Transmission: Earliest citation of germline transmission: J:172582
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Vector: L1L2_gt2 Flp-mediated recombination removed the lacZ and neo cassette and left exon 2 floxed. (J:172582)

Generation of the Aspa^tm1a(EUCOMM)Wtsi and Aspa^tm1c(EUCOMM)Wtsi alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aspa Mutation: 26 strains or lines available

References

• Original: J:172582 Mersmann N, et al., Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease. PLoS One. 2011;6(5):e20336
• All: 2 reference(s)