Pkd2l1^tm1.1Yuni
Targeted Allele Detail

Summary

• Symbol: Pkd2l1^tm1.1Yuni
• Name: polycystic kidney disease 2-like 1; targeted mutation 1.1, Yuzo Ninomiya
• MGI ID: MGI:5008611
• Gene: Pkd2l1 Location: Chr19:44136076-44180881 bp, - strand Genetic Position: Chr19, 36.91 cM
• Alliance: Pkd2l1^tm1.1Yuni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172581
• Parent Cell Line: EF1 (ES Cell)
• Strain of Origin: 129S/SvEv x C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exons 3 through 9 were replaced with an IRES-mCherry and self-excising neo cassette. The neo cassette removed itself. No fluorescence expression was observed. Immunohistochemistry confirmed the absences of protein expression in taste tissue. (J:172581)

Generation of the Pkd2l1^tm1.1Yuni allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pkd2l1 Mutation: 50 strains or lines available

References

• Original: J:172581 Horio N, et al., Sour Taste Responses in Mice Lacking PKD Channels. PLoS One. 2011;6(5):e20007
• All: 7 reference(s)