Tg(PDGFB-UCHL1*I93M)LWada
Transgene Detail

Summary

• Symbol: Tg(PDGFB-UCHL1*I93M)LWada
• Name: transgene insertion L, Keiji Wada
• MGI ID: MGI:5008736
• Synonyms: hUCHL1^I93M
• Transgene: Tg(PDGFB-UCHL1*I93M)LWada Location: unknown
• Alliance: Tg(PDGFB-UCHL1*I93M)LWada page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-UCHL1*I93M)LWada expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  UCHL1 (7345)

  Uchl1

  (MGI:103149)

  Transgene codes for a protein with a isoleucine to methionine mutation.

• Mutation details: The human PDGFB promoter drives expression of a human UCHL1 cDNA with an isoleucine to methionine mutation at amino acid 93(I93M). Two lines were generated. Line L had lower levels of transgene expression compared to line H. In the L line expression was only detected in male mice. (J:128045)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128045 Setsuie R, et al., Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant. Neurochem Int. 2007 Jan;50(1):119-29
• All: 1 reference(s)