Tg(PDGFB-UCHL1*I93M)HWada
Transgene Detail

Summary

• Symbol: Tg(PDGFB-UCHL1*I93M)HWada
• Name: transgene insertion H, Keiji Wada
• MGI ID: MGI:5008738
• Synonyms: H-hI93M, hUCHL1^I93M
• Transgene: Tg(PDGFB-UCHL1*I93M)HWada Location: unknown
• Alliance: Tg(PDGFB-UCHL1*I93M)HWada page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-UCHL1*I93M)HWada expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  UCHL1 (7345)

  Uchl1

  (MGI:103149)

• Mutation details: The human PDGFB promoter drives expression of a human UCHL1 cDNA with an isoleucine to methionine mutation at amino acid 93(I93M). Two lines were generated. Line L had lower levels of transgene expression compared to line H. Expression of the transgene is detected in the many brain regions including the substantia nigra, subthalamic nuclei, striatum, hippocampus CA3 and cerebellum. (J:128045)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128045 Setsuie R, et al., Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant. Neurochem Int. 2007 Jan;50(1):119-29
• All: 2 reference(s)