Ncstn^tm1.1Akli
Targeted Allele Detail

Summary

• Symbol: Ncstn^tm1.1Akli
• Name: nicastrin; targeted mutation 1.1, Apostolos Klinakis
• MGI ID: MGI:5009035
• Synonyms: Ncstn^f
• Gene: Ncstn Location: Chr1:171893580-171910356 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Ncstn^tm1.1Akli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172442
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked pgk-neo cassette and loxP sit were inserted into intron 4 and a loxP site was inserted into intron 7 via homologous recombination. Flp mediated recombination removed the pgk-neo cassette leaving exons 5-7 floxed. (J:172442)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncstn Mutation: 34 strains or lines available

References

• Original: J:172442 Klinakis A, et al., A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature. 2011 May 12;473(7346):230-3
• All: 7 reference(s)