Gt(ROSA)26Sor^{tm1(Flt1,EGFP)Dlam}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Flt1,EGFP)Dlam}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Diether Lambrechts
• MGI ID: MGI:5009041
• Synonyms: FLT1^WT, stop^loxFLT1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Flt1,EGFP)Dlam} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Flt1,EGFP)Dlam} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Flt1 (MGI:95558)

• Mutation details: The Flt1 sequence was cloned downstream of an in-frame loxP flanked STOP cassette (lox-neo-lox) and upstream of an IRES sequence followed by the EGFP sequence. In the presence of cre recombinase, the STOP cassette is removed and expression of Flt1 results. Flt1 expression levels are 20% higher in whole dorsal root ganglia compared to wild-type. (J:172783)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:172783 Dhondt J, et al., Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons. FASEB J. 2011 May;25(5):1461-73
• All: 1 reference(s)