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Gt(ROSA)26Sortm2(VEGFB*)Dlam
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm2(VEGFB*)Dlam
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Diether Lambrechts
MGI ID: MGI:5009043
Synonyms: stoploxVEGF-B186
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm2(VEGFB*)Dlam page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172783
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm2(VEGFB*)Dlam expresses 1 gene
 
Mutation detailsThe human VEGFB isoform 186 sequence was cloned downstream of an in-frame loxP flanked STOP cassette (lox-neo-lox). In the presence of cre recombinase, the STOP cassette is removed and expression of VEGF-B<186> results. (J:172783)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:172783 Dhondt J, et al., Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons. FASEB J. 2011 May;25(5):1461-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory