Gt(ROSA)26Sortm2(VEGFB*)Dlam
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm2(VEGFB*)Dlam |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Diether Lambrechts |
MGI ID: |
MGI:5009043 |
Synonyms: |
stoploxVEGF-B186 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm2(VEGFB*)Dlam page
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Germline Transmission: |
Earliest citation of germline transmission:
J:172783
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm2(VEGFB*)Dlam expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
VEGFB (7423) |
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Mutation details: The human VEGFB isoform 186 sequence was cloned downstream of an in-frame loxP flanked STOP cassette (lox-neo-lox). In the presence of cre recombinase, the STOP cassette is removed and expression of VEGF-B<186> results.
(J:172783)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
993 strains or lines available
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Original: |
J:172783 Dhondt J, et al., Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons. FASEB J. 2011 May;25(5):1461-73 |
All: |
1 reference(s) |
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