Adamts4^tm1.1Boer
Targeted Allele Detail

Summary

• Symbol: Adamts4^tm1.1Boer
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 4; targeted mutation 1.1, Derek Boerboom
• MGI ID: MGI:5009124
• Synonyms: Adamts4^-
• Gene: Adamts4 Location: Chr1:171077990-171088206 bp, + strand Genetic Position: Chr1, 79.28 cM
• Alliance: Adamts4^tm1.1Boer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172645
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed exons 2 and 3. (J:172645)

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts4 Mutation: 49 strains or lines available

References

• Original: J:172645 Boerboom D, et al., Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn. 2011 Jul;240(7):1806-14
• All: 2 reference(s)