Rr162^tm3.1Wtg
Targeted Allele Detail

Summary

• Symbol: Rr162^tm3.1Wtg
• Name: regulatory region 162; targeted mutation 3.1, William T Garrard
• MGI ID: MGI:5009316
• Synonyms: Igk^tm3.1Wtg, Sis^-
• Gene: Rr162 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr162^tm3.1Wtg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172855
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A 3.7 kb region containing the silencer in the Vkappa-Jkappa intervening sequence (Sis) was flanked with a loxP site on one side and a loxP site flanked neomycin resistance gene cassette on the other. Cre-mediated recombination removed the neo cassette and Sis. (J:172855)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr162 Mutation: 0 strains or lines available

References

• Original: J:172855 Xiang Y, et al., A multifunctional element in the mouse Igkappa locus that specifies repertoire and Ig loci subnuclear location. J Immunol. 2011 May 1;186(9):5356-66
• All: 1 reference(s)