Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp
Transgene Detail

Summary

• Symbol: Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp
• Name: transgene insertion #a, David M Spencer
• MGI ID: MGI:5009680
• Synonyms: JOCK-1, JOCK1
• Transgene: Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp Location: unknown
• Alliance: Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Fgfr1
  Not Specified	Fkbp1a

• Mutation details: The promoter drives prostate epithelium-specific expression of the intracellular domain with a 5' myristolation site and, at the 3', two tandem AP20187 drug binding domains for chemically induced dimerization and an HA tag. The one unnamed line that was generated is referred to as #a. (J:87092)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pbsn-Fgfr1/Fkbp1a)#aDmsp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:87092 Freeman KW, et al., Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice. Cancer Res. 2003 Dec 1;63(23):8256-63
• All: 5 reference(s)