Adam8^tm1.1Rood
Targeted Allele Detail

Summary

• Symbol: Adam8^tm1.1Rood
• Name: a disintegrin and metallopeptidase domain 8; targeted mutation 1.1, G David Roodman
• MGI ID: MGI:5009706
• Gene: Adam8 Location: Chr7:139558845-139572475 bp, - strand Genetic Position: Chr7, 84.96 cM, cytoband F3-F5
• Alliance: Adam8^tm1.1Rood page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172936
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of eoxn 6. A floxed neo cassette was inserted downstream of exon 17. Cre-mediated recombination removed the neo cassette and exons 6 through 17. The absence of transcript expression was confirmed by semi-quantitative RT-PCR. (J:172936)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam8 Mutation: 45 strains or lines available

References

• Original: J:172936 Ishizuka H, et al., ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo. J Bone Miner Res. 2011 Jan;26(1):169-81
• All: 1 reference(s)