Dkk1^tm1.1Svo
Targeted Allele Detail

Summary

• Symbol: Dkk1^tm1.1Svo
• Name: dickkopf WNT signaling pathway inhibitor 1; targeted mutation 1.1, Seppo Vainio
• MGI ID: MGI:5013423
• Synonyms: Dkk1^c, Dkk1^flox
• Gene: Dkk1 Location: Chr19:30523276-30526896 bp, - strand Genetic Position: Chr19, 25.16 cM, cytoband C2
• Alliance: Dkk1^tm1.1Svo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173125
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette. (J:173125)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dkk1 Mutation: 18 strains or lines available

References

• Original: J:173125 Pietila I, et al., Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling. Dev Biol. 2011 May 1;353(1):50-60
• All: 12 reference(s)