Dkk1^tm1.2Svo
Targeted Allele Detail

Summary

• Symbol: Dkk1^tm1.2Svo
• Name: dickkopf WNT signaling pathway inhibitor 1; targeted mutation 1.2, Seppo Vainio
• MGI ID: MGI:5013424
• Synonyms: Dkk1^del, Dkk1ⁿ
• Gene: Dkk1 Location: Chr19:30523276-30526896 bp, - strand Genetic Position: Chr19, 25.16 cM, cytoband C2
• Alliance: Dkk1^tm1.2Svo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173125
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre-mediated recombination of Dkk1^tm1.1Svo removed exons 1 and 2. (J:173125)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dkk1 Mutation: 18 strains or lines available

References

• Original: J:173125 Pietila I, et al., Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling. Dev Biol. 2011 May 1;353(1):50-60
• All: 1 reference(s)