Pax9^{tm1.1(Osr2)Jian}
Targeted Allele Detail

Summary

• Symbol: Pax9^{tm1.1(Osr2)Jian}
• Name: paired box 9; targeted mutation 1.1, Rulang Jiang
• MGI ID: MGI:5013428
• Synonyms: Pax9^del
• Gene: Pax9 Location: Chr12:56738552-56759607 bp, + strand Genetic Position: Chr12, 24.53 cM
• Alliance: Pax9^{tm1.1(Osr2)Jian} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173121
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Pax9^{tm1.1(Osr2)Jian} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Osr2 (MGI:1930813)

• Mutation details: A loxP site was inserted into exon 1 upstream of the ATG. A cassette containing (5' to 3') a loxP site, an FRT-flanked neo resistance marker, and a myc-tagged Osr2 cDNA with a polyadenylation sequence was inserted downstream of exon 2. Cre-mediated recombination removed part of exon 1 and all of exon 2. (J:173121)

Expression

In Mice Carrying this Mutation:

41 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax9 Mutation: 17 strains or lines available

References

• Original: J:173121 Zhou J, et al., Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev Biol. 2011 May 15;353(2):344-53
• All: 6 reference(s)