Ltbr^tm1Mmat
Targeted Allele Detail

Summary

• Symbol: Ltbr^tm1Mmat
• Name: lymphotoxin B receptor; targeted mutation 1, Mitsuru Matsumoto
• MGI ID: MGI:5013450
• Gene: Ltbr Location: Chr6:125283534-125290848 bp, - strand Genetic Position: Chr6, 59.32 cM
• Alliance: Ltbr^tm1Mmat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173115
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A floxed cassette containing a lacZ gene, polyadenylation sequence, FRT-flanked neo cassette, and a second polyadenylation sequence was inserted downstream of exon 1. (J:173115)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ltbr Mutation: 47 strains or lines available

References

• Original: J:173115 Mouri Y, et al., Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. J Immunol. 2011 May 1;186(9):5047-57
• All: 6 reference(s)