Bmx^tm1.1Npa
Targeted Allele Detail

Summary

• Symbol: Bmx^tm1.1Npa
• Name: BMX non-receptor tyrosine kinase; targeted mutation 1.1, Novartis Pharma AG
• MGI ID: MGI:5013470
• Synonyms: BMX^{tm1(K421R)Npa}
• Gene: Bmx Location: ChrX:162975838-163041189 bp, - strand Genetic Position: ChrX, 76.12 cM, cytoband F
• Alliance: Bmx^tm1.1Npa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173099
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotides substitutions in exon 14 result in the amino acid substitution of arginine for lysine at position 421 (K421R). This mutation responds to the human mutation K445R that results in the loss of kinase activity. A floxed neo cassette was removed by cre-mediated recombination. (J:173099)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmx Mutation: 12 strains or lines available

References

• Original: J:173099 Gottar-Guillier M, et al., The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner. J Immunol. 2011 May 15;186(10):6014-23
• All: 2 reference(s)