Cop1^tm1.1Vmd
Targeted Allele Detail

Summary

• Symbol: Cop1^tm1.1Vmd
• Name: COP1, E3 ubiquitin ligase; targeted mutation 1.1, Vishva M Dixit
• MGI ID: MGI:5013593
• Synonyms: Cop1^delta1
• Gene: Cop1 Location: Chr1:159059890-159175210 bp, + strand Genetic Position: Chr1, 69.03 cM, cytoband C3
• Alliance: Cop1^tm1.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172653
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ reporter gene and a floxed neo cassette. Cre-mediated recombination removed the neo cassette. (J:172653)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cop1 Mutation: 44 strains or lines available

References

• Original: J:172653 Vitari AC, et al., COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature. 2011 Jun 16;474(7351):403-6
• All: 3 reference(s)