Cop1^tm2.1Vmd
Targeted Allele Detail

Summary

• Symbol: Cop1^tm2.1Vmd
• Name: COP1, E3 ubiquitin ligase; targeted mutation 2.1, Vishva M Dixit
• MGI ID: MGI:5013594
• Synonyms: Cop1^fl
• Gene: Cop1 Location: Chr1:159059890-159175210 bp, + strand Genetic Position: Chr1, 69.03 cM, cytoband C3
• Alliance: Cop1^tm2.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172653
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette. (J:172653)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cop1 Mutation: 44 strains or lines available

References

• Original: J:172653 Vitari AC, et al., COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature. 2011 Jun 16;474(7351):403-6
• All: 4 reference(s)