Abcc10^tm1Eah
Targeted Allele Detail

Summary

• Symbol: Abcc10^tm1Eah
• Name: ATP-binding cassette, sub-family C member 10; targeted mutation 1, Elizabeth A Hopper-Borge
• MGI ID: MGI:5013608
• Gene: Abcc10 Location: Chr17:46614146-46638954 bp, - strand Genetic Position: Chr17, 22.9 cM
• Alliance: Abcc10^tm1Eah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172648
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 6 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on kidney cell lines and spleen extracts. (J:172648)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc10 Mutation: 58 strains or lines available

References

• Original: J:172648 Hopper-Borge EA, et al., Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10-/- Mice. Cancer Res. 2011 May 15;71(10):3649-3657
• All: 2 reference(s)