Panx1^tm1.2Vmd
Targeted Allele Detail

Summary

• Symbol: Panx1^tm1.2Vmd
• Name: pannexin 1; targeted mutation 1.2, Vishva M Dixit
• MGI ID: MGI:5013648
• Gene: Panx1 Location: Chr9:14917081-14956774 bp, - strand Genetic Position: Chr9, 4.52 cM
• Alliance: Panx1^tm1.2Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173213
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette, and cre-mediated recombination removed exon 2. The absence of protein expression was confirmed by western blot analysis on muscle, lung, liver, spleen, kidney, tail, brain, heart, thymus, and bone marrow-derived macrophage extracts. (J:173213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Panx1 Mutation: 38 strains or lines available

References

• Original: J:173213 Qu Y, et al., Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation. J Immunol. 2011 Jun 1;186(11):6553-61
• All: 19 reference(s)