Birc2^tm1Rbr
Targeted Allele Detail

Summary

• Symbol: Birc2^tm1Rbr
• Name: baculoviral IAP repeat-containing 2; targeted mutation 1, Robert Brink
• MGI ID: MGI:5013654
• Synonyms: Birc2^flox, cIap1^flox
• Gene: Birc2 Location: Chr9:7818228-7837065 bp, - strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Birc2^tm1Rbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172843
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. A floxed hygro cassette was inserted downstream of exon 1. (J:172843)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Birc2 Mutation: 33 strains or lines available

Notes

This allele was originally generated in ES cells containing Birc3^tm1Rbr.

References

• Original: J:172843 Gardam S, et al., Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood. 2011 Apr 14;117(15):4041-51
• All: 12 reference(s)