Birc3^tm1.1Rbr
Targeted Allele Detail

Summary

• Symbol: Birc3^tm1.1Rbr
• Name: baculoviral IAP repeat-containing 3; targeted mutation 1.1, Robert Brink
• MGI ID: MGI:5013655
• Gene: Birc3 Location: Chr9:7848700-7873187 bp, - strand Genetic Position: Chr9, 2.46 cM, cytoband A2
• Alliance: Birc3^tm1.1Rbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172843
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• FLP-mediated recombination removed exon 2, exon 3, and the neo cassette. (J:172843)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Birc3 Mutation: 32 strains or lines available

References

• Original: J:172843 Gardam S, et al., Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood. 2011 Apr 14;117(15):4041-51
• All: 8 reference(s)