Usp4^tm1Xilu
Targeted Allele Detail

Summary

• Symbol: Usp4^tm1Xilu
• Name: ubiquitin specific peptidase 4 (proto-oncogene); targeted mutation 1, Xiongbin Lu
• MGI ID: MGI:5013819
• Gene: Usp4 Location: Chr9:108225052-108269744 bp, + strand Genetic Position: Chr9, 59.25 cM
• Alliance: Usp4^tm1Xilu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173192
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 7 and 8 were replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on heart, muscle, spleen, kidney, and liver extracts. (J:173192)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp4 Mutation: 41 strains or lines available

References

• Original: J:173192 Zhang X, et al., USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J. 2011 Jun 1;30(11):2177-89
• All: 2 reference(s)